Stimulatory effects of opioids

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Stimulatory effects of opioids.

Opioid receptors exist as three principle types, known as , and and have been recently reclassifed by an International Union of Pharmacology subcommittee as OP1( ), OP2( ) and OP3( ). All three receptors have been cloned, 45 87 99 and have pharmacological characteristics consistent with those of endogenous receptors. Multiple isoforms of each subtype have been proposed on pharmacological ground...

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Modelling of the Eeg Effects of Opioids

The objective of this investigation was to characterize the role of complex biophase distribution kinetics in the pharmacokinetic-pharmacodynamic correlation of a wide range of opioids. Following intravenous infusion of morphine, alfentanil, fentanyl, sufentanil, butorphanol and nalbuphine the time course of the EEG effect was determined in conjunction with blood concentrations. Different bioph...

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Effects of opioids on driving ability.

Driving has been regarded as an activity of daily living that is important in maintaining a person's independence in the community, access to employment, and social activities. Many patients, however, using opioid medications on a regular basis (Chronic Opioid Analgesic Therapy: COAT) to ameliorate their intractable pain have been restricted from driving out of concern that skills would be impa...

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ژورنال

عنوان ژورنال: British Journal of Anaesthesia

سال: 1998

ISSN: 0007-0912

DOI: 10.1093/bja/81.1.20